Appeal No. 2001-0163
Application No. 08/951,502
Yamashita describes a process of separating an optical isomer. The process
employs a simulated moving bed system. The packed bed of the simulated moving
bed system contains a silica gel having carried thereon an optically active high-
molecular compound or a low-molecular compound. (Col. 2, ll. 20-33).
Both Ikeda ‘852 and Ikeda ‘635 disclose preparative liquid chromatography
which contains polysaccharide derivatives in the stationary phase. The polysaccharide
derivatives are disclosed to have a separation coefficient greater than that of
polysaccharide derivatives supported on silica gel. (Ikeda ‘635, p. 2; and Ikeda ‘852,
cols. 1 and 3).
Appellant argue, Brief, pages 11-12, that there is a significant pressure
difference between a simulated moving bed multicolumn chromatography and a single
column (stationary phase) liquid chromatography. In support of their position,
Appellant cite the Okamoto, Negawa and Nagamatsu references. Thus, the Appellant
assert that a person of ordinary skill in the art would not look to references that
describe single column (stationary phase) liquid chromatography (low pressure
system), i.e., Ikeda ‘852 and Ikeda ‘635, to determine suitable packing materials for a
simulated moving bed multicolumn chromatography process (high pressure system).
(Brief, p. 13).
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