Ex Parte ANDREW et al - Page 13



          Appeal No. 2001-0550                                                        
          Application No. 09/030,792                                                  

          is common knowledge in the art that trypsin functions most                  
          optimally at temperatures above room temperature, it is not clear           
          to us that preheating the enzyme solution would be of any                   
          practical benefit in the practice of Spina’s method.  As we see             
          it, given the relatively long time period (12-96 hours) over                
          which Spina’s enzyme works, and the elevated temperature that               
          exists within the eye relative to room temperature, it may very             
          well be that any initial preheating of the enzyme would have, at            
          best, only a negligible effect on the overall efficiency of                 
          Spina’s method.  The mere fact that the prior art could be so               
          modified would not have made the modification obvious unless the            
          prior art suggested the desirability of the modification (see In            
          re Gordon, 733 F.2d 900, 902, 221 USPQ 1125, 1127 (Fed. Cir.                
          1984)).  Spina contains no such suggestion.                                 
               For these reasons, the rejection of claim 1, as well as                
          claims 2, 9 and 11 that depend therefrom, as being anticipated by           
          or, in the alternative, obvious in view of Spina will not be                
          sustained.                                                                  





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