Ex Parte AXEL et al - Page 13


                Appeal No.  2001-0562                                                    Page 13                   
                Application No.  08/460,478                                                                        
                examiner relies (Answer, page 19) on ‘979 to teach “using a herpes viral vector                    
                to deliver genes encoding lysosomal enzymes, such as an hexosaminidase,                            
                glucocerebrosidase, hypoxanthine and phosphoribosyl transferase (HGPRT)                            
                known to be involved in human diseases, to cells of the nervous system both for                    
                basic and clinical research (gene therapy) involving diseases affecting the                        
                nervous system….”                                                                                  
                       In response appellants argue (Brief, page 23), ‘979 does not cure the lack                  
                of evidence of a teaching, suggestion, or motivation to combine these                              
                references.”  For the reasons set forth, supra, we agree.                                          































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