Ex parte VAZQUEZ et al. - Page 8


                  Appeal No.  2001-0598                                                              Page 8                   
                  Application No.  08/451,090                                                                                 
                                                       DISCUSSION                                                             
                         To establish a prima facie case of obviousness, there must be more than the                          
                  demonstrated existence of all of the components of the claimed subject matter.                              
                  There must be some reason, suggestion, or motivation found in the prior art                                 
                  whereby a person of ordinary skill in the field of the invention would make the                             
                  substitutions required.  That knowledge cannot come from the applicants' disclosure                         
                  of the invention itself.  Diversitech Corp. v. Century Steps, Inc.,                                         
                  850 F.2d 675, 678-79, 7 USPQ2d 1315, 1318 (Fed. Cir. 1988); In re Geiger,                                   
                  815 F.2d 686, 688, 2 USPQ2d 1276, 1278 (Fed. Cir. 1987); Interconnect Planning                              
                  Corp. v. Feil, 774 F.2d 1132, 1143, 227 USPQ 543, 551 (Fed. Cir. 1985).                                     
                         Structural relationships have, in the past, provided the requisite motivation or                     
                  suggestion to modify known compounds to obtain new compounds; see, e.g., In re                              
                  May, 574, F.2d 1082, 197 USPQ 601 (CCPA 1978) (stereoisimers); In re Wilder,                                
                  563 F.2d 457, 195 USPQ 426 (CCPA 1977) (adjacent homologs and structural                                    
                  isomers); In re Hoch, 428 F.2d 1341, 166 USPQ 406 (CCPA 1970) (acid and ethyl                               
                  ester).  As set forth in In re Deuel, 51 F.3d 1552, 1558, 34 USPQ2d 1210, 1214:                             
                         a prior art compound may suggest its homologs because homologs                                       
                         often have similar properties and therefore chemists of ordinary skill                               
                         would ordinarily contemplate making them to try to obtain compounds                                  
                         with improved properties.  Similarly, a known compound may suggest                                   
                         its analogs or isomers, either geometric isomers (cis v. trans) or                                   
                         position isomers (e.g., ortho v. para).                                                              
                  Similarly, as set forth in In re Payne, 606 F. 2d 303, 313-314, 203 USPQ 245, 254-                          
                  255 (CCPA 1979):                                                                                            
                         An obviousness rejection based on similarity in chemical structure                                   
                         and function entails the motivation of one skilled in the art to make a                              






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