Ex Parte VAN DYKE - Page 5



              Appeal No.  2001-1164                                                                 Page 5                 
              Application No. 08/293,745                                                                                   
              relied on additional evidence of non-obviousness attached to the Reply Brief, viz.,                          
              Exhibits 1, 2, 3, and 4.  Although it does not appear that applicant made a showing                          
              under Rule 195,1 nevertheless, the examiner has not favored the record with a                                
              statement respecting the entry of this additional evidence.  The examiner has not stated                     
              whether Exhibits 1, 2, 3, and 4 have been entered and considered.  If those exhibits                         
              have been entered and considered, the examiner has offered no explanation why they                           
              do not provide an effective rebuttal of the rejection under 35 U.S.C. § 103.                                 
                     We are presented in this appeal with a large number of claims of varying scope.                       
              These claims include:                                                                                        
                     (1)    a method for treating, and thereby reducing, specified drug resistant                          
                            cancers in a patient;                                                                          
                     (2)    a pharmaceutical composition for treating multidrug resistant disease                          
                            other than tuberculosis;                                                                       
                     (3)    a pharmaceutical kit;                                                                          
                     (4)    a method for treating a multidrug resistant disease;                                           
                     (5)    a method for treating, and thereby reducing, multidrug resistant cancer in                     
                            a patient by potentiating a primary anti-cancer drug to which said cancer                      
                            exhibits multidrug resistance;                                                                 
                     (6)    a method for treating, and thereby reducing drug resistant cancer in a                         
                            patient; and                                                                                   
                     (7)    a pharmaceutical composition for reducing specified drug resistant                             
                            cancers in a patient.                                                                          


                     The examiner lumps all of applicant's claims together, rejecting them as a group                      
              under 35 U.S.C. § 103 as unpatentable over a combination of seven prior art references                       



                     1   §1.195  Affidavits or declarations after appeal.                                                  
                     Affidavits, declarations, or exhibits submitted after the case has been                               
                     appealed will not be admitted without a showing of good and sufficient                                
                     reasons why they were not earlier presented.                                                          





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