Ex Parte PARADISSIS et al - Page 2


                 Appeal No. 2001-1909                                                         Page 2                    
                 Application No. 09/016,786                                                                             

                        Claims 50 and 59 are illustrative of the claims on appeal and read as                           
                 follows:                                                                                               
                 50.    A method of optimizing the regeneration, maintenance or repair of nerve                         
                 tissue that occurs naturally during sleep in a human, which comprises:                                 
                 administering to the human a therapeutically effective amount of a composition                         
                 consisting essentially of at least one water-soluble B complex Vitamin                                 
                 independently selected from the group consisting of Vitamin B1, (Thiamine),                            
                 Niacinamide, Folic Acid, Riboflavin (Vitamin B2), Pantothenic Acid (Vitamin B3),                       
                 Vitamin B6, Pyridoxine, Vitamin B12,                                                                   
                        wherein the water-soluble B complex Vitamin is administered at night to                         
                 optimize the regeneration, maintenance or repair of nerve tissue that occurs                           
                 naturally during sleep resulting from the presence of said B complex Vitamin.                          
                 59. A method of optimizing the regeneration, maintenance or repair of nerve                            
                 tissue that occurs naturally during sleep in a human, which comprises:                                 
                 administering to the human,                                                                            
                        (a) a first composition comprising at least one water-soluble B complex                         
                 Vitamin independently selected from the group consisting of Thiamine,                                  
                 Niacinamide, Pyridoxine, Folic Acid, and Riboflavin, said first composition being                      
                 released over an extended period of time from six hours up to twenty-four hours;                       
                 and                                                                                                    
                        (b) a second composition comprising at least one B complex Vitamin                              
                 selected from the group consisting of Vitamin B12 and Pantothenic Acid, said                           
                 second composition being administered as an immediate release agent;                                   
                        wherein the water-soluble B complex Vitamin is administered at night to                         
                 optimize the regeneration, maintenance or repair of nerve tissue that occurs                           
                 naturally during sleep resulting from the presence of said B complex Vitamin.                          
                        The references relied upon by the examiner are:                                                 
                 Zappia                            U.S. 4,042,698               August 16, 1977                        
                 Briggs et al. (Briggs)             U.S. 4,752,479               June 21, 1988                          
                 Radebaugh et al (Radebaugh) U.S. 4,806,359                      February 21, 1989                      
                 Koltringer                        U.S. 5,118,505               June 2, 1992                           
                 Edgren et al. (Edgren)             U.S. 5,204,116               April 20, 1993                         
                 Serfontein                        U.S. 5,254,572               October 19, 1993                       


                        The rejections are:2                                                                            
                                                                                                                        
                 2  The examiner has withdrawn previously-applied rejections under 35 USC §§ 112 and 102. See           
                 Examiner’s Answer, p. 2.                                                                               





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