Ex Parte PARADISSIS et al - Page 3


                 Appeal No. 2001-1909                                                         Page 3                    
                 Application No. 09/016,786                                                                             


                 1. Claims 50-52 and 54 stand rejected under 35 U.S.C. § 103(a) as being                                
                     unpatentable over Koltringer.                                                                      
                 2. Claims 50-61 stand rejected under 35 U.S.C. § 103(a) as being unpatentable                          
                     over Koltringer by itself or in combination with Zappia or Serfontein.                             
                 3. Claims 56-61 stand rejected under 35 U.S.C. § 103(a) as being unpatentable                          
                     over Koltringer by itself or in combination with Zappia or Serfontein, further in                  
                     view of Briggs.                                                                                    
                 4. Claims 56-57 and 59-61 are rejected under 35 U.S.C. § 103(a) as being                               
                     unpatentable over 1) Koltringer by itself or in combination with Zappia or                         
                     Serfontein, or 2) Koltringer by  itself  or  in  combination  with  Zappia  or                     
                     Serfontein, further in view of Briggs as set forth above, further in view of                       
                     either Edgren or Radebaugh.                                                                        

                                                   BACKGROUND                                                           
                        The specification (p. 1), describes the invention as related to                                 
                     methods for treating disease states, and particularly to a method for the                          
                     prevention and treatment of certain disease states in humans by the                                
                     continuous administration of vitamins and minerals.                                                
                 The invention is based on (specification, p. 3)                                                        
                     [t]he discovery that the efficacy of vitamins and other nutritional agents in                      
                     treating and preventing various disease states may be improved by                                  
                     administering therapeutically effective levels of these agents on a                                
                     substantially continuous, i.e., over 24-hour period.                                               
                        Three aspects to the invention are disclosed (see specification, pp. 3-4):                      
                     1. “a method of reducing the concentration of lipid peroxides formed by the                        
                        autoxidation of lipids in a human, … on a substantially continuous 24-hour                      
                        basis, a therapeutically effective amount of a pharmaceutically-acceptable                      
                        antioxidant agent”;                                                                             
                     2. “a method of reducing the concentration of oxygen free radicals in a                            
                        human, … on a substantially continuous 24-hour basis, a therapeutically                         
                        effective amount of a pharmaceutically-acceptable antioxidant agent”;                           
                        and,                                                                                            
                     3. “a method of improving the regeneration of nerve tissue in a human …,                           
                        which comprises administering to the human, on a substantially                                  





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