Ex Parte CARCASONA et al - Page 10




              Appeal No. 2001-1947                                                                                        
              Application 08/333,202                                                                                      
              claimed purity.   In our view, this evidence has been insufficiently rebutted by the                        
              examiner.                                                                                                   
                     In our view, and consistent with legal precedent, a compound in purer or modified                    
              form may, if unobvious in that form, be patentable over the same compound as it                             
              existed in the prior art but the claims thereto must be limited so as to exclude from the                   
              scope thereof, the compound as it existed in nature.   In re Kebrich, 201 F.2d 951, 954,                    
              96 USPQ 411, 413 (CCPA 1953).  Compare In re Williams, 171 F.2d 319, 320,   80                              
              USPQ 150, 152 (CCPA 1948).  We find appellants have sufficiently limited the                                
              scope of their purer form of diacetylrhein to a diacetylrhein containing less than 20 ppm                   
              aloe-emodin components.                                                                                     
                     It has also been held that compound/substance extracted from its parent material                     
              even in purer form is patentable only if it possesses a utility not possessed     by the                    
              patent material and not evident from the art.   Ex parte Reed, 135 USPQ 34                                  
              (Bd. App. 1962).   In our view, appellants have established that the state of the art is                    
              that prior art methods of preparing diacetylrhein, and therefore prior art products                         
              produced from these methods, have not provided a diacetylrhein product with less than                       
              20 ppm of aloe-emodin.   Appellants also provide evidence that the claimed product                          
              differs from prior art products in its mutagenicity properties.                                             






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