Appeal No. 2001-2093 Application No. 09/054,134 temperatures and pH conditions appropriate for the process described in DE ’715 would have been within the level of the ordinary skill in the art. Boesch, 617 F.2d at 276, 205 USPQ at 219; Aller, 220 F.2d at 456, 105 USPQ at 235; Geisler, 116 F.3d at 1469, 43 USPQ2d at 1365. The appellants argue that Günter aims to maintain low viscosity homogeneous reaction conditions, while DE ’715 relates to insoluble polymeric reactants. (Appeal brief, page 5; reply brief filed Mar. 2, 2001, paper 27, pages 2-3.) This argument is not persuasive. As we discussed above, one of ordinary skill in the art would have known from the prior art that reaction variables, such as temperature or pH conditions, are parameters that must be taken into account in determining the appropriate process conditions for alkylating tertiary amines, regardless of whether the reactant is a compound or a polymer. Buske, which is discussed in detail in the reply brief (page 3), further supports this view. (Column 6, lines 4-25.) The appellants urge that practicing the claimed process at the recited temperatures and pH conditions overcomes “known difficulties.” (Appeal brief, page 4.) We note, however, that the appellants’ position is not supported by sufficient evidence. While the appellants rely on the declaration under 37 8Page: Previous 1 2 3 4 5 6 7 8 9 10 11 12 NextLast modified: November 3, 2007