Ex Parte SMITH et al - Page 6



              Appeal No. 1996-0288                                                                  Page 6                
              Application No. 07/873,634                                                                                  
                     when dealing with particular combinations of prior art and specific claims,                          
                     but must set forth the rationale on which it relies.                                                 
              In re Lee, 277 F.3d at 1345, 61 USPQ2d at 1435.                                                             
                     Here, the examiner has not adequately explained that the problem which forms                         
              the basis for his first proposed reason for combining the references would have been                        
              present and so recognized by a person of ordinary skill in the art.  A fact-based                           
              explanation is needed as to why the Cox product produced under anaerobic conditions                         
              would expectedly contain so much oxygen that an active oxygen absorber would be                             
              needed.  We do not find that the examiner has properly established a prima facie case                       
              of obviousness.                                                                                             
                     The examiner’s second alternative reason for combining the teachings of Cox                          
              and Kasugai also lacks factual support in the record.  The examiner asserts it would                        
              have been obvious to place an oxygen absorber in the culture media system of Cox “in                        
              order to generate the anaerobic atmophere of Cox.”  If the examiner’s assertion is                          
              viewed in the context of the combined disclosures of Cox and Kasugai without resort to                      
              appellants’ description of the present invention, it is not apparent on what basis one of                   
              ordinary skill in the art would have found it obvious to replace the glove box system of                    
              Cox with the package of active oxygen absorber of Kasugai.  Absent a fact-based                             
              explanation of the examiner’s reasoning in support of this proposed substitution, we do                     
              not find that the examiner has properly established a prima facie case of obviousness.                      
                     Having found the examiner has not established a prima facie case of                                  
              obviousness, we need not consider appellants' evidence of nonobviousness.                                   
                     The decision of the examiner is reversed.                                                            






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