MILLER et al v. AVIV et al - Page 6




         Patent Interference No. 103,925                       Page 6               

         APPENDIX 2                                                                 
         Ø Claims 31-32, 34-35, 37-38, 40-41 and 57 of Miller '745 application:     
         31. A composition of DNA molecules which consists of DNA molecules encoding bovine
         growth hormone comprising the amino acid sequence:                         
         10                                                                         
         phe pro ala met ser leu ser gly leu phe ala asn ala val leu                
         20                                      30                                 
         arg ala gln his leu his gln leu ala ala asp thr phe lys glu                
         40                                                                         
         phe glu arg thr tyr ile pro glu gly gln arg tyr ser ile gln                
         50                                      60                                 
         asn thr gln val ala phe cys phe ser glu thr ile pro ala pro                
         70                                                                         
         thr gly lys asn glu ala gln gln lys ser asp leu glu leu leu                
         80                                      90                                 
         arg ile ser leu leu leu ile gln ser trp leu gly pro leu gln                
         100                                                                        
         phe leu ser arg val phe thr asn ser leu val phe gly thr ser                
         110                                     120                                
         asp arg val tyr glu lys leu lys asp leu glu glu gly ile leu                
         130                                                                        
         ala leu met arg glu leu glu asp gly thr pro arg ala gly gln                
         140                                     150                                
         ile leu lys gln thr tyr asp lys phe asp thr asn met arg ser                
         160                                                                        
         asp asp ala leu leu lys asn tyr gly leu leu ser cys phe arg                
         170                                     180                                
         lys asp leu his lys thr glu thr tyr leu arg val met lys cys                
         190 191                                                                    
         arg arg phe gly glu ala ser cys ala phe.                                   
         32. A recombinant DNA molecule which comprises a segment encoding a protein in a
         condition substantially free of DNA encoding bovine pituitary protein other than bovine
         growth hormone, wherein said segment encodes a protein comprising the amino acid
         sequence:                                                                  
         10                                                                         
         phe pro ala met ser leu ser gly leu phe ala asn ala val leu                
         20                                      30                                 
         arg ala gln his leu his gln leu ala ala asp thr phe lys glu                
         40                                                                         
         phe glu arg thr tyr ile pro glu gly gln arg tyr ser ile gln                
         50                                      60                                 
         asn thr gln val ala phe cys phe ser glu thr ile pro ala pro                
         70                                                                         







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