Ex Parte GROTENDORST et al - Page 11


                  Appeal No. 2002-0427                                                            Page 11                     
                  Application No. 08/179,656                                                                                  

                  present claim language was first introduced, Appellants described an enclosed                               
                  declaration as showing that “the amino terminal portion of LDGF is responsible                              
                  for the PDGF-like biological activity of the molecule, i.e., immunoreactivity.”                             
                  While an applicant can be his own lexicographer, any alternative meaning must                               
                  be clearly indicated in the specification.  See Optical Disc Corp. v. Del Mar                               
                  Avionics, 208 F.3d 1324, 1334, 54 USPQ2d 1289, 1295 (Fed. Cir. 2000)                                        
                  (“Without evidence in the patent specification of an express intent to impart a                             
                  novel meaning to a claim term, the term takes on its ordinary meaning.”).                                   
                         Finally, the claims state that the amino acid change in the claimed protein                          
                  vis-à-vis SEQ ID NO:17 “does not affect the reactivity of the protein.”  The                                
                  particular “reactivity” that remains unaffected is another source of ambiguity.  The                        
                  specification mentions LDGF2 functions of “reacting with the PDGF receptor”                                 
                  (page 5, line 7), as well as “reacting with the PDGF receptor and/or acting as a                            
                  mitogen or chemoattractant.”  LDGF2 may have other reactivities that are                                    
                  unknown.                                                                                                    
                         “[D]uring patent prosecution when claims can be amended, ambiguities                                 
                  should be recognized, scope and breadth of language explored, and clarification                             
                  imposed.”  In re Zletz, 893 F.2d 319, 322, 13 USPQ2d 1320, 1322 (Fed. Cir.                                  
                  1989).  If the instant claims are subject to further examination, the examiner                              
                  should consider whether the language of the claims is sufficiently definite.                                











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