Ex Parte COOK et al - Page 6




          Appeal No. 2002-0795                                                        
          Application No. 09/128,036                                                  

          of reagents/reactants in the apparatus and method of Cody would             
          have frustrated the purpose and testing procedure taught by this            
          reference.  See In re Gurley, supra.                                        
               The examiner states that the motivation for modifying Cody             
          with the mixtures of reactants of Smith is that Smith teaches               
          that “use of mixtures can provide simplicity to the reactions and           
          workup (see page 2822, top).”  Answer, page 4 (see also pages 6             
          and 8).  However, the only teaching found on page 2822 (top) of             
          Smith is that “[t]he synthesis utilises a very simple chemical              
          coupling protocol and does not generate any biproducts which                
          could interfere with biological assays.”  The examiner has not              
          explained why the chemical coupling protocol of Smith is simpler            
          than the chemical coupling disclosed by Cody or why the “workup”            
          of Smith, directed to a mixture of many similar products, would             
          have been easier or simpler than the “workup” of Cody, which is             
          directed to the preparation of only one compound per reaction               
          tube.  Therefore we determine that the motivation proposed by the           
          examiner is not sufficiently supported by the evidence of record.           
               The examiner’s alternate motivations to combine the                    
          references, i.e., “structural similarity,” and “design choice or            
          optimization” (Answer, page 6), are also not supported by any               
          convincing evidence on this record.  The examiner has failed to             

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