Appeal No. 2002-0795 Application No. 09/128,036 of reagents/reactants in the apparatus and method of Cody would have frustrated the purpose and testing procedure taught by this reference. See In re Gurley, supra. The examiner states that the motivation for modifying Cody with the mixtures of reactants of Smith is that Smith teaches that “use of mixtures can provide simplicity to the reactions and workup (see page 2822, top).” Answer, page 4 (see also pages 6 and 8). However, the only teaching found on page 2822 (top) of Smith is that “[t]he synthesis utilises a very simple chemical coupling protocol and does not generate any biproducts which could interfere with biological assays.” The examiner has not explained why the chemical coupling protocol of Smith is simpler than the chemical coupling disclosed by Cody or why the “workup” of Smith, directed to a mixture of many similar products, would have been easier or simpler than the “workup” of Cody, which is directed to the preparation of only one compound per reaction tube. Therefore we determine that the motivation proposed by the examiner is not sufficiently supported by the evidence of record. The examiner’s alternate motivations to combine the references, i.e., “structural similarity,” and “design choice or optimization” (Answer, page 6), are also not supported by any convincing evidence on this record. The examiner has failed to 6Page: Previous 1 2 3 4 5 6 7 8 9 NextLast modified: November 3, 2007