Ex Parte STILL et al - Page 5


                 Appeal No. 2003-1722                                                         Page 5                    
                 Application No. 09/041,343                                                                             

                 case is not one, like Lilly, in which a chemical compound was defined by its                           
                 function rather than its structure.                                                                    
                 2.  Enablement                                                                                         
                        The examiner also rejected claims 112, 117, and 125 for nonenablement.                          
                 The examiner acknowledged that the claims were enabled for “synthetic                                  
                 receptors with diaminoazepine (6 member ring with Nitrogen heterocycle) or                             
                 diaminopyrrolidine (5 member ring with Nitrogen heterocycle) as templates.”                            
                 Examiner’s Answer, page 5.1  The examiner nonetheless rejected the claims as                           
                 broader than the enabling disclosure, on the basis that the specification “does not                    
                 reasonably provide enablement for synthetic receptors with templates which are                         
                 monocyclic heterocycles with more than 6 member ring and presence of other                             
                 heterocycle atoms such as Oxygen or sulfur in addition to Nitrogen.”  Id.                              
                        The examiner apparently concluded that the specification was deficient in                       
                 teaching those skilled in the art both how to make and how to use the claimed                          
                 products.  The examiner’s conclusion that the specification does not teach how to                      
                 make the claimed library relied heavily on the proposition that the claims “contain                    
                 no specific chemical structure of the templates.”  Examiner’s Answer, page 5.  In                      
                 addition, the examiner concluded that, even assuming “that one could make                              
                 synthetic receptors, . . . as encompassed by the present claims, the specification                     


                                                                                                                        
                 1 The examiner’s citation of “diaminoazepine (6 member ring with Nitrogen heterocycle)” as one         
                 enabled species leaves the precise scope of enablement conceded somewhat unclear.                      
                 Diaminoazepine, of course, has a 7-membered heterocyclic ring; the corresponding heterocycle           
                 with a 6-membered ring is diaminopiperidine.  For the reasons discussed infra, however, the            
                 issue is moot.                                                                                         





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