Ex Parte BUECHLER et al - Page 6



              Appeal No. 2003-2084                                                                Page 6                
              Application No. 08/241,061                                                                                

              provides adequate written descriptive support for the language questioned by the                          
              examiner.                                                                                                 
                     If the examiner's real concern is that the language set forth in claim 102 does not                
              appear verbatim in the specification, the examiner should require appellants to comply                    
              with 37 CFR § 1.75(d)(1)("The claim or claims must conform to the invention as set                        
              forth in the remainder of the specification and the terms and phrases used in the claims                  
              must find clear support or antecedent basis in the description so that the meaning of                     
              the terms in the claims may be ascertainable by reference to the description.")                           
                     The rejection of claim 102 under 35 U.S.C. § 112, first paragraph (written                         
              description), is reversed.                                                                                
              2.  Written Description Rejection of Claims 98 and 99.                                                    
                     The rejection is explained as follows:                                                             
                            The specification description directed [sic] is directed to specific                        
                     crosstalk inhibitors which resemble the chemical structure which links the                         
                     ligand analogue to the carrier, for example the crosstalk inhibitors                               
                     disclosed in figures 1C to 1F, which clearly do not provide an adequate                            
                     representation regarding the open ended claimed composition comprising                             
                     the crosstalk inhibitors, ligand analogue conjugates attached to a protein                         
                     made of the presently claimed invention.                                                           
                            And moreover, applicants have not shown that they are in                                    
                     possession of a composition which has plurality of different ligand                                
                     analogue conjugates, each different ligand analogue conjugate has a                                
                     different linkage site from the linkage of the other ligand analogue                               
                     conjugates.                                                                                        
              Examiner’s Answer, page 5.                                                                                
                     The examiner relies upon the University of Calif. v. Eli Lilly & Co., 119 F.3d 1559,               
              1567, 43 USPQ2d 1398, 1405 (Fed. Cir. 1997), stating "[a]lthough directed to DNA                          
              compounds, this holding would be deemed to be applicable to any compound; which                           




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