Ex Parte BUECHLER et al - Page 11



              Appeal No. 2003-2084                                                               Page 11                
              Application No. 08/241,061                                                                                

              been withdrawn as to these two claim limitations, we conclude that the continued                          
              maintenance of this aspect of the rejection is an oversight on the part of the examiner.                  
                     We will also reverse the remainder of the rejection.  The examiner first questions                 
              the phrase "ligand analogue conjugate" as used in claims 98-108 stating "[i]t is not clear                
              what does [sic] applicants mean by analogue."   However, as set forth above, the                          
              specification provides an explicit definition of "ligand analogue conjugate."                             
              Furthermore, this aspect of the rejection is contrary to the issuance of the '524 patent                  
              by the USPTO since claims of that patent are also directed to ligand analogue                             
              conjugates.                                                                                               
                     The examiner next questions the phrase "analogue of linkage site" as used in                       
              claims 98-99, stating "[t]he specification no where teaches what are the analogues of                     
              the linkage site.  And the specification no where teaches how are the analogues in the                    
              linkage site can be [sic] prepared."  Examiner's Answer, page 9.  The specific questions                  
              raised by the examiner in regard to this claim language appear to be more directed to                     
              enablement rather than exploring the metes and bounds of the claim language.  The                         
              examiner has not established that one skilled in the art would have any difficulty in                     
              determining whether a given compound would be considered an "analogue of the                              
              linkage site" as this phrase is used in claims 98 and 99.  Again, this aspect of the                      
              rejection is in conflict with the issuance of the '524 patent by the USPTO since the                      
              phrase "analogue of the linkage site" is used in claim 3 of the '524 patent.                              
                     The next aspect of the rejection is the use of the phrase “standard immunological                  
              technique” in claim 98 with the examiner stating: “it is not clear what does [sic]                        
              applicants mean by ’standard immunological techniques[‘].  Does applicant [sic] mean                      




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