CHEN et al. v BOUCHARD et al. - Page 126



          Interference No. 103,675                                                      

              differs from that of a proton oriented in the opposite                    
              direction.                                                                
              The protons are then exposed within                                       
              the NMR instrument to a radio frequency excitation that can               
              change their orientation. This excitation gives rise to a                 
              signal from each proton. After a Fourier transform treatment              
              carried out by the NMR instrument, a spectrum showing all                 
              the signals is produced.                                                  
              In the spectrum, the signals                                              
              corresponding to each proton experience a displacement                    
              generally to the left of an axis referenced at * 0 ppm. This              
              displacement (*), commonly referred to as chemical shift                  
              value in ppm, is largely determined by the nature of the                  
              chemical group(s) to which the atom, in general a carbon,                 
              bearing the proton in question, is bonded. ...                            
                                                                                       
              An NMR spectrum is                                                        
              sometimes referred to as the fingerprint of a compound. For               
              any compound containing protons, the chemical shifts of the               
              different protons are largely determined by the neighboring               
              atoms and are considered as characteristic. Thus, NMR can be              
              used to verify or disprove a proposed structure of a                      
                                       126                                              


Page:  Previous  119  120  121  122  123  124  125  126  127  128  129  130  131  132  133  Next 

Last modified: November 3, 2007