Interference No. 103,675
compound.
Thus, while NMR is capable of verifying a proposed structure, except
for uncomplicated compounds such as benzene, for example, which has
six equivalent protons (hydrogens) and presents a single,
characteristic peak for its NMR spectrum, NMR spectra can be complex
because of the effects the various neighboring atoms and their
substituents have on the protons attached to specific carbon atoms and
are subject to interpretation. The testimony of Drs. Nicolaou and
Parker and the testimony of Drs. Kingston (CR 1823, lines 15 through
24; CR 1825, lines 1 through 10), Kant (CR 2169) and Kadow (CR 40, 41)
and the testimony of Ms. Huang (CR 664-665, 674) and others confirms
that without other physical data characteristic of the unknown
compound or without an NMR spectrum for a known sample of what the
unknown compound is believed to be, NMR spectra are subject to
interpretation and are not, necessarily definitive as to the structure
of an unknown.
More significantly, the Chen et al. record does not include
any definitive evidence which establishes exactly what material was
subjected to NMR spectroscopy. Thus, we are left to conjecture whether
or not pure compounds were tested or mixtures of compounds including
starting materials and various products were tested. Identification
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