A virus particle of claim 1, wherein the non-segmented RNA virus is vesicular stornatitus
virus (VSV). [Wertz claim 5)
OR
A virus particle of claim 6, wherein the non-segmented RNA virus is vesicular stomatitis
virus. [Wertz claim 10]
OR
A modified recombinant replicable vesiculovirus, comprising vesiculovirus N, P, and L
proteins, and a replicable vesiculovirus genomic sense (-) RNA, in which said genomic sense
RNA, is modified by:
(a) the insertion of a foreign or heterologous RNA sequence into a
nonessential portion of said replicable vesiculovirus genomic sense
RNA; or
(b) the replacement of a nonessential portion of said replicable vesiculovirus
genomic sense (-) RNA with a foreign or heterologous RNA sequence;
in which an RNA sequence complementary to said foreign RNA sequence encodes a peptide or
protein. [Rose claim 75, as amended]
OR
A modified inactivated recombinant vesiculovirus that is the produce of a method
comprising inactivating a recombinant replicable vesiculovirus, said recombinant replicable
vesiculovirus comprising N, P, and L proteins, and a replicable vesiculovirus genomic sense
RNA, in which said genomic sense (-) RNA, is modified by:
(c) the insertion of a foreign or heterologous RNA sequence into a
nonessential portion of said replicable vesiculovirus genomic sense
RNA; or
(d) the replacement of a nonessential portion of said replicable vesiculovirus
genomic sense (-) RNA with a foreign or heterologous RNA sequence;
in which an RNA sequence complementary to said foreign RNA sequence encodes a peptide or
protein. [Rose claim 103, as amended]
OR
A pure, recombinant, replicating and infectious vesicular stomatitus virus (VSV) particle,
comprising:
3
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Last modified: November 3, 2007