Interference 105,004 Paper 18
DeBoer v. Gordon
The count:
2. Count 1, the sole count, is:
a transgenic bovine according to claim 7 of
Deboer 6,140,552 or a transgenic bovine
according to claim 18 of Gordon, 08/246,259.
3. DeBoer claim 7 is:
A bovine whose mammary gland cells have a
genome comprising in operable association:
a DNA sequence encoding a signal
sequence functional in bovine mammary gland
secretory cells;
a DNA sequence encoding a polypeptide of
interest; and
a regulatory sequence that promotes
expression of the DNA sequence encoding the
polypeptide in the mammary gland;
wherein the bovine or a female
descendant of the bovine is disposed to
express the transgene in mammary secretory
cells such that the polypeptide of interest
is detectable in milk produced by the bovine
or a female descendant of the bovine;
wherein the polypeptide is a
heterologous polypeptide.
4. Gordon claim 18 is:
A non-human mammal whose genome comprises a
DNA construct comprising a whey acidic
protein promoter operably linked to a DNA
sequence encoding a heterologous protein,
wherein said construct further comprises a
DNA sequence encoding a secretory peptide
operatively linked to said DNA sequence
encoding a heterologous protein, wherein said
mammal is selected from the group consisting
of mouse, sheep, pig, goat and cow, and
wherein said heterologous protein is
expressed in the milk of the mammal.
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