Interference No. 105,099 Paper 25
Hannum v. Immunex Corp. Page 2
[2] According to Immunex,2 flt3-ligand ("flt3-L")
refers to a genus of polypeptides that bind and complex independently
with flt3 receptor found on progenitor and stem cells. The term "flt3-L"
encompasses proteins having the amino acid sequence 1 to 231 of SEQ
ID NO:2 or the amino acid sequence 1 to 235 of SEQ ID NO:6, as well as
those proteins having a high degree of similarity or a high degree of
identity with the amino acid sequence 1 to 231 of SEQ ID NO:2 or the
amino acid sequence 1 to 235 of SEQ ID NO:6, and which proteins are
biologically active and bind the flt3 receptor. In addition, the term refers to
biologically active gene products of the DNA of SEQ ID NO:1 or SEQ ID
NO:5. Further encompassed by the term "flt3-L" are the membrane-bound
proteins (which include an intracellular region, a membrane region, and an
extracellular region), and soluble or truncated proteins which comprise
primarily the extracellular portion of the protein, retain biological activity
and are capable of being secreted. Specific examples of such soluble
proteins are those comprising the sequence of amino acids 28-163 of
SEQ ID NO:2 and amino acids 28-160 of SEQ ID NO:6.
[3] Count 1, the sole count, is (Paper 13 at 4):
A polypeptide of Immunex 806 claim 49.
[4] Immunex 806 claim 49 is [2003]:4
An isolated polypeptide that binds to flt3, wherein said polypeptide
comprises amino acids 28-163 of SEQ ID NO:2.
[5] Immunex SEQ ID NO:2 is a 231-residue polypeptide [2001].
[6] All of the claims of both parties correspond to the count (Paper 1 at 4):
Hannum 168 claims 54-74
Hannum 882 claims 28-30
Immunex 806 claims 49-58
2 3001 at ¶0026.
3 Notice Declaring Interference. Hannum has provided a copy of the declaration [2002]. The filing of
duplicate papers is discouraged (Paper 2, Standing Order, at § 12).
4 Hannum exhibits are numbered from 2001.
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