Interference No. 105,099 Paper 25
Hannum v. Immunex Corp. Page 7
Immunex: LVLLAAAWGLRWQRARRRGELHPGVPLPSHP 231
[23] The Hannum claimed subsequences are identically contained within Immunex SEQ ID
NO:2, and within the range specified in the count (28-163) provided the unknown ("X")
in Hannum SEQ ID NO:2 is asparagine ("N") as Hannum discloses in its specification.
[24] Neither party appears to be contending that the invention of Immunex 806 claim 49,
which is based on Immunex SEQ ID NO:2, anticipates the invention of Hannum 882
claim 28. From this, we infer that the non-sequence physical characteristics recited in
Hannum's claim are met by flt3 ligands with sequences similar to Immunex SEQ ID
NO:2.
[25] The Hannum claimed subsequences are consensus sequences that appear to be
based on murine (mouse) isoforms of flt3 ligand [3002 at 8:32-11:38].
[26] Immunex SEQ ID NO:2 is a murine sequence [e.g., 3001 at 0050].
[27] Hannum discloses three separate murine flt3 ligand isoforms (MoT118,9 MoT110,10 and
MB8) and two human isoforms (HuS86 and HuS109). The murine isoforms match
against Immunex SEQ ID NO:2 as follows (where "." indicates a gap, bold indicates a
difference, and underlining indicates the Hannum claimed subsequences):
Immunex: MTVLAPAWSPNSSLLLLLLLLSPCLRGTPDCYFSHSPISS 40
MoT118: MTVLAPAWSPNSSLLLLLLLLSPCLRGTPDCYFSHSPISS 40
MoT110: MTVLAPAWSPNSSLLLLLLLLSPCLRGTPDCYFSHSPISS 40
MB8: MTVLAPAWSPNSSLLLLLLLLSPCLRGTPDCYFSHSPISS 40
9 Hannum SEQ ID NO:40.
10 Hannum SEQ ID NO:38
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