Interference No. 105,099 Paper 25
Hannum v. Immunex Corp. Page 8
Immunex: NFKVKFRELTDHLLKDYPVTVAVNLQDEKHCKAL...... 74
MoT118: NFKVKFRELTDHLLKDYPVTVAVNLQDEKHCKAL...... 74
MoT110: NFKVKFRELTDHLLKDYPVTVAVNLQDEKHCKAL...... 74
MB8: NFKVKFRELTDHLLKDYPVTVAVNLQDEKHCKALDRVSLL 80
Immunex: .......................WSLFLAQRWIEQLKTVA 91
MoT118: .......................WSLFLAQRWIEQLKTVA 91
MoT110: .......................WSLFLAQRWIEQLKTVA 91
MB8: CRLGLTLNSLQSSCLSVLSAGITWSLFLAQRWIEQLKTVA 120
Immunex: GSKMQTLLEDVNTEIHFVTSCTFQPLPECLRFVQTNISHL 131
MoT118: GSKMQTLLEDVNTEIHFVTSCTFQPLPECLRFVQTNISHL 131
MoT110: GSKMQTLLEDVNTEIHFVTSCTFQPLPECLRFVQTNISHL 131
MB8: GSKMQTLLEDVNTEIHFVTSCTFQPLPECLRFVQTNISHL 160
Immunex: LKDTCTQLLALKPCIFKACQNFSRCLEVQCQPDSSTLLPP 171
MoT118: LKDTCTQLLALKPCIFKACQNFSRCLEVQCQPGNGGPRAQ 171
MoT110: LKDTCTQLLALKPCIFKACQNFSRCLEVQCQPDSSTLLPP 171
MB8: LKDTCTQLLALKPCIFKACQNFSRCLEVQCQPDSSTLLPP 200
Immunex: RSPIALEATELPEPRPRQLLLLLLLL.PLTLVLLAAAWGL 210
MoT118: HHGATRLTATALLTVCPGLLLPLVGT.SHMFFLPYFLSFL 210
MoT110: RSPIALEATELPEPRPRQLLLLLLLLLPLTLVLLAAAWGL 211
MB8: RSPIALEATELPEPRPRQLLLLLLLLLPLTLVLLAAAWGL 240
Immunex: RWQRARRRGELHPGVPLPSHP 231
MoT118: SSFLKMYLYV........... 220
MoT110: RWQRARRRGELHPGVPLPSHP 232
MB8: RWQRARRRGELHPGVPLPSHP 261
[28] The examiner argues that a consensus sequence between the three Immunex isoforms
would yield Immunex SEQ ID NO:2. If we ignore MB8 as simply a variant of MoT110, it
is not clear how one skilled in the art would choose a consensus sequence between the
two isoforms. Alternatively, if MB8 is considered, the simplest consensus sequence
(majority rule at each differing position, gaps permitted) would yield the MoT110
sequence, which differs from Immunex SEQ ID NO:2 by the addition of a leucine
residue at position 198.
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