Ex Parte Somerville et al - Page 5



              Appeal No. 2003-1743                                                                  Page 5                 
              Application No. 09/540,205                                                                                   

              (Examiner’s Answer, Paper No. 17, paragraph bridging pages 6 and 7).  That, however,                         
              amounts to a non sequitur.  On this record, the only motivation we can find for preparing                    
              the non-racemic mixture recited in claims 1 through 21 stems from applicants’                                
              specification, not the Gorman reference.  Again, we refer to the instant specification,                      
              page 4, lines 11 through 20.                                                                                 
                     The rejection of claims 1 through 21 for obviousness based on Gorman is                               
              reversed.                                                                                                    
                                                    Claims 22 and 23                                                       
                     It would appear that the examiner failed to address the limitations of claims 22                      
              and 23 in Paper No. 10 or in section (10) of the Examiner’s Answer setting forth the                         
              grounds of rejection.  In section (11) of the Examiner’s Answer, entitled “Response to                       
              Argument,” the examiner states that :                                                                        
                     While it was not expressly stated in paper number 10, it would have been                              
                     obvious to administer an opioid antagonist such as naloxone or naltrexone                             
                     to treat pain because narcotic antagonists can be used to counteract or                               
                     prevent excessive central nervous system depression and respiratory                                   
                     depression resulting from the methadone.  One would be motivated to                                   
                     administer such narcotic antagonists with l-methadone because l-                                      
                     methadone has a 30 fold greater ability to displace naloxone binding that                             
                     [sic] d-methadone and narcotic antagonists can be used to counteract or                               
                     prevent excessive central nervous system depression and respiratory                                   
                     depression resulting from the methadone. [Id. at page 9, last paragraph]                              
                     We point out, however, that the sole reference relied on in rejecting claims 22                       
              and 23 is Gorman.  The examiner does not cite any passage or passages in Gorman                              
              which would support the above-quoted findings in the Examiner’s Answer, page 9, last                         
              paragraph.  Simply stated, it would appear that those findings lack evidentiary support in                   
              the record.  As stated in In re Warner, 379 F.2d 1011, 1017, 154 USPQ 173, 177-78                            





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