Ex Parte MCDONNELL et al - Page 7


              Appeal No. 2003-2091                                                               Page 7                
              Application No. 09/266,465                                                                               

                    It is true that all of the elements of the claimed product are encompassed by the                  
              genera described in Zhang.  However, when a claimed product is not specifically                          
              described in a reference, but must be derived by choosing and combining different                        
              elements that are separately disclosed, the proper basis for rejection (if any) is 35                    
              U.S.C. § 103.                                                                                            
                    In response to Appellants’ argument on this point, the examiner cited guidance                     
              from the MPEP to the effect that a claimed product can be anticipated by a prior art                     
              reference, even if it is necessary to select portions of the reference and combine them,                 
              so long as the classes from which the selections are made are “sufficiently limited or                   
              well delineated.”  Examiner’s Answer, page 6 (citing MPEP § 2131.02).  The examiner                      
              also relied on the MPEP for the following proposition:                                                   
                    If one of ordinary skill in the art is able to “at once envisage” the specific                     
                    [claimed] compound within the generic [known] chemical formula, the                                
                    compound is anticipated.  One of ordinary skill in the art must be able to                         
                    draw the structural formula or write the name of each of the compounds                             
                    included in the generic formula before any of the compounds can be “at                             
                    once envisaged.”                                                                                   
              Id. (citing In re Petering, 301 F.2d 676, 133 USPQ 275 (CCPA 1962)).                                     
                    The examiner argues that this passage from the MPEP supports the rejection                         
              because “one of ordinary skill could write out the combinations of promoters and genes;                  
              indeed, many different combinations of the promoters and Bcl-2 transgenes disclosed in                   
              the ‘191 patent would anticipate the claimed invention.  For example, in claims reciting                 
              any [non-adenoviral] inducible promoter . . . many of the 17 inducible promoters listed in               
              Table 3 . . . and several of the promoters listed in Table 2 . . . combined with any of the              








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