Ex Parte Kafrawy et al - Page 18




                    Appeal No. 2004-0479                                                                                                                                  
                    Application No. 09/780,864                                                                                                                            


                    normal lighting conditions."  See Cambron, column 6, lines 17-28.                                                                                     
                    4. Cambron states in the specification that "[i]t is generally                                                                                        
                    desirable that catheters be radiopaque because it is often                                                                                            
                    necessary to determine the precise location of a catheter                                                                                             
                    within its host by X-ray examination."  See Cambron, column 1,                                                                                        
                    lines 11-14.                                                                                                                                          
                    5. Cambron states in the specification that "[i]n U.S. Patent                                                                                         
                    Nos. 3,749,134 and 3,901,829, Slingluff describes yet further                                                                                         
                    attempts to produce catheters which are optical transparent                                                                                           
                    and radiopaque.  In these patents, Slingluff suggests blending                                                                                        
                    a small amount of a diol of tetrabromophthalic anhydrite and a                                                                                        
                    plasticizer with the thermoplastic resin employed in forming                                                                                          
                    the catheter."  See Cambron, column 2, lines 26-32.                                                                                                   
                    6. Cambron states in the specification that "[u]nfortunately,                                                                                         
                    it has been discovered that such physical blends suffer from                                                                                          
                    certain drawbacks.  For example, the material blended in to                                                                                           
                    add radiopaque often can be leached from the material.  In                                                                                            
                    extreme cases, the material can be leached from the catheter                                                                                          
                    and absorbed systematically by the host."  See Cambron, column                                                                                        
                    2, lines 56-61.                                                                                                                                       


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