Ex Parte HIRSCHMAN - Page 5


                 Appeal No. 2004-1212                                                           Page 5                    
                 Application No. 09/316,624                                                                               

                         Among other things, Friedland discloses that the components of Product R                         
                 and Reticulose® have different molecular weight distributions, as well as different                      
                 ratios of UV absorbancies.  See Table IV (column 10).  Friedland also reports                            
                 that, although Kochel characterized the low molecular weight fraction of                                 
                 Reticulose® as inhibiting phagocytosis by neutrophils (see Kochel, column 2,                             
                 lines 46-55), Product R does not have similar activity.  See Table IV.  Finally,                         
                 Friedland compares the starting materials for ten-liter batches of Reticulose® and                       
                 Product R (Table V) and concludes that “the initial protein concentration for the                        
                 RETICULOSE® preparation is twice as much as that for the Product R                                       
                 preparation.”  Column 10, lines 44-46.                                                                   
                         We agree with Appellant that the evidence of record shows that the                               
                 Product R recited in the instant claims is different from the Reticulose®                                
                 preparation disclosed by Kochel.  We therefore reverse the rejection under 35                            
                 U.S.C. § 102(e).                                                                                         
                         We note in closing that the examiner may have intended the rejection to                          
                 be based more on obviousness than anticipation:  Kochel does not isolate any                             
                 low molecular weight fractions of Reticulose®, or describe how to do so, but the                         
                 section of Kochel cited by the examiner as teaching treatment of rheumatoid                              
                 arthritis states that a low molecular weight fraction of Reticulose® is “effective in                    
                 treating auto immune diseases.”  Column 3, lines 1-11.  If the examiner is of the                        
                 view that Kochel would have made obvious the instantly claimed method, even                              
                 though it does not anticipate, a rejection under 35 U.S.C. § 103 may be                                  
                 appropriate.                                                                                             





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