Interference 103,781
AR 6884-6886), but also compiling Bt and plant gene data and
constructing her own codon usage tables for a complete and
reliable representation of plant genes (AR 0094-0095;
AR 0107-0108; AR 0128; AR 4158; AR 6887-6888).
It appears from the totality of evidence that the reasons
Drs. Adang and Murray spent so much time performing experiments
related to subject matter “somewhat distinct from codon usage”
and continued compiling Bt and plant codon usage data were:
(1) On or about December 12, 1986, Drs. Adang and Murray
suspected that the evidentiary basis for their inventive concept
was incomplete and unreliable;
(2) On or about December 12, 1986, Drs. Adang and Murray
were not certain of the cause of, or mechanism causing, shorter
RNA’s than expected and inefficient production of Bt insecticidal
protein in plants transformed by native Bt gene sequences
encoding Bt insecticidal protein (AR 4157);
(3) On or about December 12, 1986, Drs. Adang and Murray
“also thought it might be the coding region of the gene was not
going to be translated very well by the plant gene” (AR 4157);
(4) On or about December 12, 1986, Drs. Adang and Murray
were not confident that their inventive concept (within the scope
of Count 2) was in “sufficiently final form that only the
exercise of ordinary skill remained to reduce it to practice.”
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