Barton et al or Fischhoff et al v. Adang et al. - Page 128




          Interference 103,781                                                        

               called electroporation that she and another scientist were             
               developing for more rapid analysis of Bt genes in plant                
               cells (AR 4156-4157; AR 6885).                                         
               (17) Drs. Adang and Murray performed experiments directed              
               towards transgenic expression systems based on constructions           
               of a series of gene deletions of natural Bt genes (e.g.,               
               electroporation), associated with heli cell extracts,                  
               designed for heat shock promoters and constructs, and used             
               to test Shaw Kamen sequences, “each of those experiments               
               were for the purpose of identifying the gene part, region              
               that needed or would benefit from fixing most . . . .  Then            
               we could go and rebuild the gene upon codon preference and             
               codon frequency” (AR 0111-0112; AR 6884-6886).                         
               (18) Drs. Adang and Murray “had . . . some experiments on              
               identifying destabilizing regions that . . . [they] were               
               following up on up until . . . August, 1988" (AR 0114-0115).           
               (19) “No,” Dr. Adang did not “believe that identifying the             
               . . . destabilizing region would be necessary in order for             
               . . . [the] invention involving increasing the number of               
               plant-preferred codons in the native Bt gene to work”                  
               (AR 0116, l. 16-21).                                                   
               (20) Dr. Murray “thought the shorter RNA’s [identified by              
               Northern blots] might have occurred due to some other                  

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