Barton et al or Fischhoff et al v. Adang et al. - Page 126




          Interference 103,781                                                        

               in plants was incomplete and that the use of that data for             
               their purposes was risky (AR 0094-0097).                               
               (6)  Drs. Adang and Murray elected to pin down a region of             
               the Bt gene that could be most easily fixed and should be              
               fixed first (AR 0107-0108).                                            
               (7)  Drs. Adang and Murray were looking for a region that              
               caused RNA instability (AR 0107-0108).                                 
               (8)  Drs. Adang and Murray considered their “search for                
               the region of . . . [the Bt gene] causing RNA instability              
               . . . somewhat distinct from codon usage” (AR 0107-0108).              
               (9)  Drs. Adang and Murray knew that Bt DNA were AT-rich               
               (AR 0123-0125; AR 4153).                                               
               (10)  Drs. Adang and Murray knew that plant DNA was GC-rich            
               (AR 0123-0125; AR 4154).                                               
               (11)  Drs. Adang and Murray suspected that plants                      
               transformed by Bt genes encoding toxin would produce more              
               toxin if the Bt DNA sequences encoding toxin were modified             
               to make them more plant-like (AR 6039-6040).                           
               (12) Drs. Adang and Murray knew that one way to make Bt DNA            
               sequences more plant-like was to modify the Bt DNA sequences           
               to include codons preferred by plants and reflect the codon            
               usage of the plant genes (AR 0123-0125; AR 4154).                      


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