Interference 103,781 in plants was incomplete and that the use of that data for their purposes was risky (AR 0094-0097). (6) Drs. Adang and Murray elected to pin down a region of the Bt gene that could be most easily fixed and should be fixed first (AR 0107-0108). (7) Drs. Adang and Murray were looking for a region that caused RNA instability (AR 0107-0108). (8) Drs. Adang and Murray considered their “search for the region of . . . [the Bt gene] causing RNA instability . . . somewhat distinct from codon usage” (AR 0107-0108). (9) Drs. Adang and Murray knew that Bt DNA were AT-rich (AR 0123-0125; AR 4153). (10) Drs. Adang and Murray knew that plant DNA was GC-rich (AR 0123-0125; AR 4154). (11) Drs. Adang and Murray suspected that plants transformed by Bt genes encoding toxin would produce more toxin if the Bt DNA sequences encoding toxin were modified to make them more plant-like (AR 6039-6040). (12) Drs. Adang and Murray knew that one way to make Bt DNA sequences more plant-like was to modify the Bt DNA sequences to include codons preferred by plants and reflect the codon usage of the plant genes (AR 0123-0125; AR 4154). -126-Page: Previous 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 NextLast modified: November 3, 2007