Interference 103,781
(13) Drs. Adang and Murray decided to approach the problem
of poor expression of Bt genes in plants by first “looking
for a specific region of the gene to modify” (AR 4155).
(14) Drs. Adang and Murray “agreed that the way to modify
. . . [the Bt gene] was to change the codon usage and
balance the ratio of AT to GC, to being more like that of
a plant, and to retain the amino acid sequence of the Bt
gene and change it to the codons preferred by the plant”
(AR 4155).
Having considered the totality of the evidence before us, we
find that, after December 12, 1986:
(15) Dr. Murray started to look for the region or regions
that caused RNA instability. Specifically, she “set about
doing a set of experiments to try and identify exactly what
sequences were at the end of the short RNA’s” found in
plants transformed by native Bt genes encoding toxin in
November 1985 (nuclease protection experiments)(AR 4155;
AR 6886) and “worked on them intermittently, doing other
experiments along the way, through August of 1987.
And . . . [she] still continued to try and complete some
experiments after August 1987 until January 1988" (AR 4156).
(16) From October ‘86 until January or February or March
1988, Dr. Murray continued to work on a “new technique”
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