Interference 103,781
of transcription. And we knew how to fix it, through
mutagenesis or building up stretches of the whole gene.
Q. Do you believe that you have any documents that show
that you and Dr. Murray did come up with this idea in
November of 1985?
A. I think all those documents collectively that I just
mentioned, the RNA analysis, the computer searches,
the AT-richness, the UCLA abstract, they all support,
corroborate this invention of Dr. Murray’s and mine.
In that vein, Dr. Adang’s subsequent testimony is most
informative. When asked how he proceeded after he and Dr. Murray
“had conceived of the idea in November of 1985" (AR 4614,
p. 1729, l. 21-23), Drs. Adang and Murray testified that they
were sidetracked in their endeavor to reduce that idea to
practice (AR 4614, p. 1729, l. 24, to p. 1730, l. 9):
A. Well, we discussed how to approach this problem, how
to go about fixing the Bt gene by replacing these AT-rich
codons with plant-preferred codons.
We thought that the quickest way to change the Bt gene
so it was highly expressed was to go into the gene and to
find those stretches of the Bt gene that were causing the
greatest problems for this - greatest problems causing lower
expression. So we designed a series of experiments to try
to identify the worst regions of the Bt gene, that we could
then go back and fix, putting in plant preferred codons.
(iii) Findings
Having considered the totality of the evidence before us, we
find that prior to December 12, 1986:
(1) Adang suspected some kind of premature termination of
transcription because Dr. Murray’s record of analysis of
-124-
Page: Previous 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 Next
Last modified: November 3, 2007