Appeal No. 2004-1736 Page 2
Application No. 09/243,008
receptor-bound target cell or a receptor-bound target infective
agent; and
the second of said receptors comprising (a) an extracellular
portion which is capable of specifically recognizing and binding said
target cell or said target infective agent, and (b) an intracellular
portion which is derived from CD28.
79. A cell which expresses at least two proteinaceous
membrane-bound chimeric receptors,
the first of said receptors comprising (a) an extracellular
portion which is capable of specifically recognizing and binding a
target cell or a target infective agent, and (b) a transmembrane
portion derived from a T cell receptor CD3, zeta, or eta polypeptide,
a B cell receptor, or an Fc receptor, and (c) an intracellular domain
that does not signal target cell or target infective agent destruction;
and
the second of said receptors comprising (a) an extracellular
portion which is capable of specifically recognizing and binding said
target cell or said target infective agent, and (b) an intracellular
portion which is derived from CD28.
The examiner does not rely on any references.
Claims 44-47, 51-52, 72-75, 79, 100 and 101 stand rejected under 35
U.S.C. § 112, first paragraph, as containing subject matter that was not
described in the specification in such a way as to reasonably convey to one
skilled in the art that the inventor(s), at the time the application was filed, had
possession of the claimed invention. After careful review of the record and
consideration of the issue before us, we reverse.
BACKGROUND
According to the Specification,
Although native T cell, B cell, and Fc receptors are or can be
highly complicated multimeric structures not lending themselves to
convenient manipulation, the present invention demonstrates the
feasibility of creating chimeras between the intracellular domain of
any variety of molecules which are capable of fulfilling the task of
target recognition. In particular, the formation of chimeras
Page: Previous 1 2 3 4 5 6 7 8 Next
Last modified: November 3, 2007