Appeal No. 2005-0192 Page 3
Application No. 09/809,021
about 5.0 to 8.0. To achieve the desired effect on use and for stabilization, then a
soluble calcium salt, sodium chloride, a sugar or a pure alcohol and/or an amino acid
. . . is added to the preparation. This results in good stabilities in the liquid and/or frozen
state for a storage time of 12 months or more.” Paragraph [0016].
“It has also emerged that addition of substances which inhibit noncovalently the
thrombin activity in vitro can seemingly only increase the stability even further,
especially at room temperature, by diminishing the autolysis of thrombin. Suitable
substances for this purpose are compounds such as benzamidine or
p-aminobenzamidine.” Paragraph [0017].
“The thrombin preparations produced by the described process can be employed
inter alia as components of a fibrin glue [in combination with fibrin and optionally factor
XIII].” Paragraph [0020]. “Finally, the thrombin concentrates produced according to the
invention can also be employed alone or in combination with carrier materials as agent
for local stoppage of bleeding.” Paragraph [0021].
Discussion
The claims stand or fall together. Appeal Brief, page 5. Since the broadest claim
subject to each rejection is claim 18, we will consider that claim as representative.
Claims 19 and 35-38 will stand or fall with claim 18.
Claim 18 is directed to a thrombin preparation which is “suitable for therapeutic
purposes,” comprising thrombin and “a noncovalently binding inhibitor of thrombin
1 The instant application’s official Image File Wrapper contains images of very poor quality; nearly every
page is partially illegible. Therefore, our citations to the specification refer to the version of the application
that was published on October 25, 2001 as Publication No. 2001/0033837.
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