Ex Parte Polonsky et al - Page 4


                     Appeal No.  2005-0258                                                                           Page 4                        
                     Application No.  09/768,877                                                                                                   
                     We agree.  In re Gardner, 427 F.2d 786, 788, 166 USPQ 138, 140 (CCPA 1970)                                                    
                     (“[b]readth is not indefiniteness.”).  In our opinion, a person of ordinary skill in the                                      
                     art reading appellants’ claimed invention in light of their specification would                                               
                     understand that the claims are open to include a method of screening for a                                                    
                     modulator of the function of any “calpain 10” of any structure               3 from any organism.                             
                     Accordingly, we reverse the rejection of claims 18-21, 49-51, 53-64, 115 and 116                                              
                     under 35 U.S.C. § 112, second paragraph.                                                                                      


                     New Matter:                                                                                                                   
                              Claims 19, 49 and 53 stand rejected under 35 U.S.C. § 112, first                                                     
                     paragraph.4  According to the examiner (Answer, page 6), “[t]his is a new matter                                              
                     rejection.”  In this regard, the examiner finds (Answer, bridging paragraph, pages                                            
                     6-7), claims 19, 49 and 53                                                                                                    
                              encompass a method of screening for a modulator of calpain 10                                                        
                              function wherein the calpain 10 polypeptide used comprises amino                                                     
                              acids 1-47 of SEO ID NO: 2.  While the specification discloses a                                                     
                              method as described above wherein the calpain 10 polypeptide                                                         
                              used is that of SEQ ID NO: 2, the Examiner has been unable to                                                        
                              locate adequate support in the specification for a method of                                                         
                              screening for a modulator of calpain 10 function with a calpain 10                                                   
                              polypeptide which comprises specifically amino acids 1-47 of SEQ                                                     
                              ID NO: 2.  Furthermore, the Examiner has not been able to find a                                                     
                              specific reference to amino acids 1-47 of SEQ ID NO: 2.  Thus                                                        
                              there is no indication that methods using specifically calpain 10                                                    
                              polypeptides which comprise amino acids 1-47 of SEQ ID NO: 2                                                         
                                                                                                                                                   
                     3 We note, however, that claims 19, 49, 50, and 53 limit the structure of the calpain 10                                      
                     polypeptide by requiring that “the calpain 10 polypeptide comprises amino acid 1 to 47 of SEQ ID                              
                     NO:2.”  In addition, we note that claims 115 and 116 limit the source of the calpain 10 polypeptide                           
                     to a human calpain 10.                                                                                                        
                                                                                                                                                  
                     4 As we understand the examiner’s rejection, claim 49 was included in the rejection because it                                
                     depends from claim 19.  We note, however, that claim 50, depends from claim 49.  Accordingly, it                              
                     is unclear why claim 50 was not also included in this rejection.                                                              





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