Appeal No. 2005-0258 Page 6
Application No. 09/768,877
CAPN10 gene. Alternative splicing generates eight related but structurally
distinct proteins.” These eight proteins are identified as CALPAIN 10a, 10b, 10c,
10d, 10e, 10f, 10g and 10h. See Table 1, specification, page 30. As set forth in
Table 1, all eight proteins comprise exon 1. As discussed above, exon 1
encodes amino acids 1-47 of SEQ ID NO:2. In the “summary of the invention”
section of appellants’ specification (page 7), appellants disclose that “the
invention relates to methods of screening for modulators of calpain function
comprising the steps of: a) obtaining an [sic] calpain polypeptide.” On page 8 of
the specification, appellants disclose
[t]he invention also relates to isolated and purified calpain 10
polypeptides, for example, polypeptides forming calpain 10a,
calpain 10b, calpain 10c, calpain 10d, calpain 10e, calpain 10f,
calpain 10g, [and] calpain 10h…. Such polypeptides may have an
amino acid sequence as set forth in any of SEQ ID NO:2, SEQ ID
NO: 4, SEQ ID NO: 6, SEQ ID NO: 8, SEQ ID NO: 10, SEQ ID NO:
12, SEQ ID NO: 14, [and] SEQ ID NO: 16….
Table 1 at page 30 of appellants’ specification discloses that SEQ ID NOs: 2, 4,
6, 8, 10, 12, 14 and 16 correspond to calpain 10a, 10b, 10c, 10d, 10e, 10f, 10g,
and 10h respectively.
For the foregoing reasons we reverse the rejection of claims 19, 49 and 53
under 35 U.S.C. § 112, first paragraph.
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