Ex Parte Regnier et al - Page 12




             Appeal No. 2005-1216                                                                                    
             Application No. 10/117,453                                                                              
             separated by a recessed area (sump) in a manner which is said to prevent transport of                   
             a sample between adjacent support surfaces.                                                             
                    To that end, we find that Hillenkamp I and II1 disclose sample holders which are                 
             used to analyze samples by a technique known as matrix-assisted laser desorption and                    
             ionization (MALDI) mass spectrometry.  See, e.g., Hillenkamp I, the abstract, col. 1,                   
             lines 4-5, col. 2, lines 51-59, col. 9, lines 36-41; Hillenkamp II, the abstract, col. 1, lines         
             13-14, col. 2, lines 58-67.  Hillenkamp I provides several figures exemplifying various                 
             embodiments of the invention, including Figures 10-12B.2  In our view, Figure 10                        
             illustrates a sample holder having each and every limitation set forth in claim 30.  That               
             is, we find that the sample holder in Figure 10 has a multiplicity of islands comprising a              
             sample support surface and which are connected through a substrate.  Hillenkamp I                       
             does not disclose locking the islands into the sample plate or their removal for                        
             subsequent sample analysis, and we find nothing in Figure 10 which indicates that they                  
             [the islands] are not non-removably connected.  We further find that the recessed area                  
             (sump) between the islands clearly separates the adjacent sample support surfaces and                   
             thus, manifestly, inhibits the transport of sample from one support surface to the next.                


                    1 Hillenkamp II is entitled to the benefit of the earlier-filed parent application for           
             those sections of the specification which are identical to the Hillenkamp I disclosure.                 
             See, e.g., Hillenkamp II, col. 9, line 53- col. 10, line 13.  Thus, we direct our discussion            
             to the teachings of Hillenkamp I.                                                                       
                    2 Although Figures 10-12B are not described by Hillenkamp I, they are                            
             nevertheless part of the published patent and are available as prior art.  See our                      
             discussion on page 13.                                                                                  
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