Ex Parte Regnier et al - Page 15




             Appeal No. 2005-1216                                                                                    
             Application No. 10/117,453                                                                              
             teachings in col. 9, lines 22-42, of Hillenkamp I anticipate a sample holder comprising a               
             multiplicity of islands, which are non-removably connected to one another through a                     
             substrate wherein said islands comprise a sample support surface and [said islands] are                 
             separated by a recessed area or sump in a manner which inhibits transport of a sample                   
             between adjacent support surfaces as set forth in claim 30.                                             
                    The appellants argue that column 9 (lines 24-31), of Hillenkamp I which states:                  
                    Thus for example the substrate 2 [sic] may consist of a plate having a plurality of              
                    thin needle-like projections or deep wells at its instrument-facing surface onto                 
                    which sample 2 is coated.  In this case, the illumination 1 provided by the laser                
                    causes desorption from the sides of the pins, or from the walls of the wells, into a             
                    space confined by the surrounding walls or adjacent pins.                                        
             does not anticipate the claimed invention.  Reply Brief, p. 4.  The appellants contend                  
             that the present invention requires “a sump that separates adjacent sample support                      
             surfaces to inhibit transport” and a sample support surface “designed to support a                      
             sample and to be individually addressable, e.g. by a laser beam.”  Id.  The appellant                   
             argues that the plume generated by the desorption of the sample from the sides of the                   
             pins “promotes mixing of sample from adjacent pins.”  Id.  We find these arguments                      
             unpersuasive.                                                                                           
                    First, we point out that representative claim 30 defines a sump as a “recessed                   
             area between adjacent sample support surfaces.”  We find that a sample plate having a                   
             plurality of needle-like projections or pins manifestly has a recessed area between the                 
             sample support surfaces.  Thus, this claim limitation is described by the Hillenkamp                    
             patents.                                                                                                

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