Appeal No. 2005-1344 Page 2
Application No. 08/468,610
Steele, 305 F.2d 859, 862, 134 USPQ 292, 295 (CCPA 1962). Accordingly, we
vacate2 the rejections of record and remand the application to the examiner to
consider the following issues and to take appropriate action.
Claims 1-5, 7-23, 55 and 56 are before us on appeal. Claims 6, and 24-54
have been cancelled3.
Claims 1 and 16 are illustrative of the subject matter on appeal and are
reproduced below:
1. A resin-protein/peptide complex which comprises a resin and a target
protein or peptide bound thereto wherein said resin comprises
a) a solid support matrix; and
b) selected ionizable ligand covalently attached to the matrix
wherein the ionizable ligand is selected such that the resin is
electrostatically uncharged at a high and a low ionic strength at the pH
where the target protein or peptide is bound to the resin wherein the
protein or peptide binds to the resin at a pH of 5 to 9 and is
electrostatically charged at the pH where the target protein or peptide is
desorbed from the resin wherein desorption occurs by a change in the
pH from the binding pH and further wherein about 50 percent or more of
the target protein or peptide in an aqueous medium binds to the resin
when the aqueous medium has either a high or a low ionic strength.
16. A resin-protein/peptide complex which comprises a resin and a target
protein or peptide bound thereto wherein said resin comprises
a) a solid support matrix having a selected ionizable functionality
incorporated into the backbone thereof wherein the ionizable
functionality is selected such that the resin is electrostatically
uncharged at a high and a low ionic strength at the pH where the
target protein or peptide is bound to the resin wherein the protein or
peptide binds to the resin at a pH of 5 to 9 and is electrostatically
charged at the pH where the target protein or peptide is desorbed
from the resin wherein desorption occurs by a change in the pH
from the binding pH; and
b) optionally a non-ionizable ligand covalently attached thereto,
wherein about 50 percent or more of the target protein or peptide in
2 Lest there be any misunderstanding, the term “vacate” in this context means to set aside or to
void. When the Board vacates an examiner’s rejection, the rejection is set aside and no longer
exists.
3 See Paper received June 6, 1995, page 2, paragraph 7.
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