Ex Parte KOPPOLU et al - Page 29




                  Appeal No. 2005-1431                                                                                                                         
                  Application 09/442,070                                                                                                                       

                            PROXIGEL, which is manufactured by Reed & Carnrick, is a 10% solution of                                                           
                            carbamide peroxide in a water free gel base.                                                                                       
                  Munro, col. 2, ll. 10-22 (emphasis added).31  Munro explains that                                                                            
                                     [i]n contrast to the prior art, the process of this invention begins                                                      
                            with a professional making a splint for the user.  The splint is,                                                                  
                            advantageously, made from a clear, very thin plastic material and is                                                               
                            designed to extend onto the user's gingiva and to fit tightly thereto so as to                                                     
                            minimize air or saliva from impacting the enclosed teeth.  The splint is                                                           
                            designed to fit one or more teeth as desired.  The user then places a drop                                                         
                            or two of the cleanser solution [(]such as the peroxide based PROXIGEL                                                             
                            solution discussed above) into the splint and places the splint, with the                                                          
                            solution inside, around the tooth or teeth and over a portion of the gingiva.                                                      
                  Id. at col. 2, l. 60 to col. 3, l. 3.                                                                                                        
                  Rosenthal discloses "an antiseptic composition comprising urea peroxide, glycerol, and a                                                     
                  carboxypolymethylene polymer," col. 1, ll. 24-25, and expresses a preference for the neutral salts                                           
                  thereof:                                                                                                                                     
                                     The preferred carboxypolymethylene polymers incorporated in such                                                          
                            compositions are copolymers of from 97.5 to 99.8 percent by weight of acrylic                                                      
                            acid and from 0.2 to 2.5 percent by weight of polyallyl sucrose having at least two                                                
                            allyl groups per sucrose molecule.  Desirably, such polymers are employed as the                                                   
                            neutral salts thereof.  By "neutral" is meant that the pH of a 1 weight percent                                                    
                            solution of the salt of the polymer has a pH of from about 5 to about 9, and                                                       
                            preferably from about 6 to about 8.                                                                                                
                  Rosenthal, col. 3, ll. 22-32 (emphasis added).  Moreover, Rosenthal's claim 1, the sole                                                      
                  independent claim, recites, inter alia, "a pharmaceutically acceptable neutral salt of a                                                     
                  carboxypolymethylene polymer."                                                                                                               

                                                                                                                                                              
                            31  This incorporating language is not quoted or discussed in the Federal Circuit's opinion.                                       
                                                                                                                                                              
                                                                             29                                                                                





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