Ex Parte STOUGHTON et al - Page 2


                 Appeal No.  2005-2235                                                           Page 2                   
                 Application No.  09/038,894                                                                              
                         32.  A method, comprising:                                                                       
                                assessing cell activation in a subject; and, if elevated,                                 
                                administering activation lowering therapy, thereby preventing a                           
                             disease or disorder or reducing the risk of a poor outcome of a                              
                             treatment of a disease or disorder.                                                          
                         The examiner does not rely on prior art.                                                         
                                             GROUNDS OF REJECTION                                                         
                         Claims 10-18, 32-36, 38, 41 and 42 stand rejected under 35 U.S.C. § 112,                         
                 second paragraph, as being indefinite for failing to particularly point out and                          
                 distinctly claim the subject matter which appellants regard as the invention.                            
                         Claims 32-36, 38, 41 and 42 stand rejected under 35 U.S.C. § 112, first                          
                 paragraph, as being based on an insufficient disclosure to support or enable the                         
                 claimed invention.                                                                                       
                         Claims 10-18, 32-36, 38, 41 and 42 stand rejected under 35 U.S.C. § 112,                         
                 first paragraph, as being based on an insufficient disclosure to support or enable                       
                 the full scope of the claimed invention.                                                                 
                         We reverse.                                                                                      
                                                     DISCUSSION                                                           
                 Definiteness:                                                                                            
                         Claims 10-18, 32-36, 38, 41 and 42 stand rejected under 35 U.S.C. § 112,                         
                 second paragraph, as being indefinite for failing to particularly point out and                          
                 distinctly claim the subject matter which appellants regard as the invention.                            
                         According to the examiner (Answer, pages 6-7), the claims are unclear                            
                 with regard to the phrases “administering activation lowering therapy” and                               







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