Ex Parte Afriat - Page 8


                Appeal No.  2005-2743                                                   Page 8                 
                Application No.  09/847,388                                                                    
                prosecution history, it does not appear that the prior art was considered in this              
                manner.  Accordingly, the record was not sufficiently developed to allow this                  
                panel to address this issue.  However, prior to taking any further action on the               
                merits, we encourage the examiner to take a step back and reconsider the                       
                claimed invention in light of the prior art.                                                   


                II.  Active agents useful in emulsions:                                                        
                      From a review of the prosecution history, it is unclear whether the                      
                examiner considered whether the prior art taught emulsions containing active                   
                agents within the scope of appellant’s claimed invention.  In this regard, we direct           
                attention to the examiner’s discussion of retinols and azelaic acid.  Answer,                  
                bridging paragraph, pages 5-6.  According to the examiner (id.), “although                     
                chemically different agents, [retinols and azelaic acid] are know in the art for               
                combating acne and related skin disorders thus … one of ordinary skill in the art              
                would be able to substitute one for the other.”  If the examiner is correct in that            
                the prior art recognizes the two compounds to be equivalent, an express                        
                suggestion to substitute one for another need not be present in order to render                
                such substitution obvious.  In re Fout, 675 F.2d 297, 301, 213 USPQ 532, 536                   
                (CCPA 1982).  We note, however, that in order to substitute azelaic acid for the               
                retinol taught by Castro, the prior art would have to not teach away from the use              
                of azelaic acid in an emulsion as taught by Castro.                                            










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