Ex Parte Wortzman et al - Page 3


                   Appeal No.  2006-0230                                                                Page 3                    
                   Application No.  09/864,083                                                                                    
                                                         DISCUSSION                                                               
                   Gordon:                                                                                                        
                          Claims 1-23 stand rejected under 35 U.S.C. § 103(a) as being obvious                                    
                   over Gordon.                                                                                                   
                          The examiner finds (Answer, page 3), Gordon “teaches a skin lightening                                  
                   composition used in the treatment of hyperpigmentation, wherein said                                           
                   composition comprising a derivative of ascorbic acid such as magnesium                                         
                   ascorbyl phosphate, [and] hydroquinone.”  Specifically, Gordon teach (column 1,                                
                   lines 44-51), compositions useful for treating and preventing hyperpigmentation                                
                   that are “at least as effective as over the counter hydroquinone preparations, with                            
                   dramatically reduced side effects.”  According to Gordon (column 1, lines 44 –                                 
                   column 2, line 5), the compositions comprise (1) tocopherol, or its dermally                                   
                   available derivatives (such as tocopherol acetate), (2) a derivative of ascorbic                               
                   acid (such as ascorbityl palmitate, magnesium ascorbityl phosphate, and                                        
                   ascorbityl linoleate), and (3) a fatty acid (such as linolenic acid).  In addition,                            
                   Gordon teach (column 2, lines 66-67), the compositions may optionally include                                  
                   1.5-4.0% hydroquinone.  For clarity, we reproduce claims 1 and 2 of the Gordon                                 
                   patent below:                                                                                                  
                          1.  A composition for the treatment of hyperpigmentation, comprising:                                   
                                  a) tocopherol or a dermally available derivative thereof,                                       
                                  b) a dermally available derivative of ascorbic acid,                                            
                                  c) a C12-C20 fatty acid,                                                                        
                                  d) a pharmaceutically acceptable carrier and                                                    
                                  e) hydroquinone.                                                                                
                          2. The composition of claim 1, wherein the derivative of ascorbic acid is                               
                              ascorbityl palmitate, ascorbityl linoleate, ascorbityl octanoate, or                                
                              magnesium ascorbityl phosphate.                                                                     






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