Appeal No. 2006-0704 Page 19
Application No. 10/060,697
sequestering function.” Stated differently, calcium sulfate aids in the development of
new bone.
Yim, however, does not teach a composition comprising demineralized bone and
cancellous bone.
Wironen
Wironen also teaches a bone repair composition comprising demineralized bone
and cancellous bone. Wironen teaches (page 3, lines 14-16), it is desirable for a bone
repair composition to be both “osteoconductive (i.e. it conducts bone cells into a region)
and osteoinductive (i.e. stem cells are induced to differentiate into bone forming cells
which begin production of new bone).” According to Wironen (page 2, lines 18-19),
demineralized bone is osteoinductive having “the ability to induce the formation of bone
even in non-osseous tissues within 4 weeks.”
Wironen discloses a composition that comprises, inter alia, three components:
i. demineralized bone;
ii. “bioactive glass ceramic, BIOGLASS®, bioactive ceramic, calcium phosphate
ceramic, hydroxyapatite, hydroxyapatite carbonate, corraline hydroxyapatite,
calcined bone, tricalcium phosphate, like material, or mixtures thereof;” and
iii. “bone morphogenetic protein [(BMP)], TGF-beta, PDGF, or mixtures thereof,
natural or recombinant.”
See, e.g., Wironen, bridging paragraph, pages 5-6. According to Wironen (page 6, lines
8-9, emphasis added), “[w]here present [the reagents of component] (ii) or like material
is included to enhance the range of manipulable characteristics of strength and
osteoinduction exhibited by the composition.”
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