Ex Parte Krieger et al - Page 2


                 Appeal No.  2006-0730                                                          Page 2                   
                 Application No.  10/164,863                                                                             
                        The examiner relies on the following reference1:                                                 
                 Merriam-Webster dictionary, http:www.m-w.com/cgi-bin/dictionary?book=                                   
                 Dictionary&va=symptom&x=13&y=14.                                                                        


                                             GROUNDS OF REJECTION                                                        
                        Claims 1-9 and 11-16 stand rejected under 35 U.S.C. § 112, first                                 
                 paragraph, as lacking adequate written descriptive support.                                             
                        Claims 1-9 and 11-16 stand rejected under 35 U.S.C. § 112, first                                 
                 paragraph, on the basis that the specification does not enable those skilled in the                     
                 art to practice the full scope of the claimed method without undue                                      
                 experimentation.                                                                                        
                        We reverse.                                                                                      


                                                    BACKGROUND                                                           
                        According to appellants (Brief, page 5), “the fertility of SR-BI KO females                      
                 . . . can be restored in the absence of ovarian and/or extraovarian SR-BI                               
                 expression by manipulations that modify the structure, composition and/or                               
                 abundance of their abnormal plasma lipoproteins.”  Accord, specification, page                          
                 28.  According to appellants (id.), “[t]hese manipulations included inactivation of                     
                 the apolipoprotein A-I gene and administration of the cholesterol-lowering drug                         
                 PROBUCOLTM.”                                                                                            


                                                                                                                         
                 1 It appears that the examiner made a typographical error in not listing the Dictionary in the          
                 “Evidence Relied Upon” section (Section No. 8) of the Answer.                                           





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