Ex Parte Krieger et al - Page 7


                 Appeal No.  2006-0730                                                          Page 7                   
                 Application No.  10/164,863                                                                             
                 the desired effect of the claimed method.”  Apparently, the examiner is                                 
                 misapprehends appellants’ claimed invention.  The claimed invention is not a                            
                 method of treating normal females with no reproductive disorders.3  To the                              
                 contrary, the claimed method is drawn to “[a] method of treating reproductive                           
                 disorders involving abnormal levels of lipids in a female mammal mediated by                            
                 SR-BI activity. . . .”  See e.g., claim 1.  Accordingly we are not persuaded by the                     
                 examiner’s argument.4                                                                                   
                        In addition, we recognize the examiner’s assertion (Answer, page 4,                              
                 emphasis removed) that it would “be unpredictable to one of ordinary skill in the                       
                 art how [sic] to alter fertility or treat any and all reproductive disorders simply by                  
                 altering lipoprotein, HDL, LDL, or cholesterol levels in a mammal, especially                           
                 since fertility and reproductive disorders all have a separate mechanism of                             
                 action. . . .”  We do not find this argument persuasive.  Contrary to the examiner’s                    
                 assertion, appellants are not claiming the treatment of “any and all reproductive                       
                 disorders.”  Instead, appellants are claiming “[a] method for treating reproductive                     
                 disorders involving abnormal levels of lipids in a female mammal mediated by                            
                 SR-BI activity.”  In our opinion, the examiner provides no reasonable basis to                          
                 conclude that treating the reproductive disorders set forth in                                          



                                                                                                                         
                 3 See e.g., Brief, page 11, wherein appellants assert “[i]f an individual has completely normal         
                 cholesterol and lipoprotein levels, there would be no reason based on this application to treat the     
                 individual with a drug to normalize their cholesterol or lipoprotein.”                                  
                 4 We are also not persuaded by the examiner’s unsupported assertion that “it would generally be         
                 expected that numerous females who have reproductive disorders would also suffer from high              
                 cholesterol” or the conclusions he would have us draw from this unsupported assertion.  Answer,         
                 page 6.                                                                                                 





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