Ex Parte Krieger et al - Page 5


                 Appeal No.  2006-0730                                                          Page 5                   
                 Application No.  10/164,863                                                                             
                 requires only a disclosure that conveys with reasonable clarity to those skilled in                     
                 the art that the inventor was in possession of the invention.  See id.                                  
                        In this case, the examiner has not adequately explained why the                                  
                 description provided by the specification would not be considered sufficient by                         
                 those skilled in the art.  We therefore reverse the rejection based on the written                      
                 description provision of 35 U.S.C. § 112, first paragraph.                                              


                 Enablement:                                                                                             
                        According to the examiner (Answer, page 3), appellants’ specification                            
                 provides an enabling disclosure of “altering fertility in female mice by knocking                       
                 out the SR-BI gene. . . .”  The examiner finds, however, appellants’ specification                      
                 fails to enable “any method of treating infertility or treating any and all                             
                 reproductive disorders by altering lipoprotein, LDL, or HDL transfer, or                                
                 cholesterol levels in a mammal.”  Id.  According to the examiner (id.), appellants                      
                 “provided no guidance and working examples of any compounds which act via                               
                 SR-BI to alter fertility . . . other than those in knockout infertile female mice.”  In                 
                 response, appellants assert (Brief, page 11), “[a]s demonstrated by the examples                        
                 at page 10, administering probucol to female mice that are deficient in SR-BI,                          
                 and characterized by abnormal lipid levels restores their fertility.  As discussed at                   
                 page 28 of the application, the results prove that it is the abnormal lipid levels                      
                 that cause the infertility.”  The examiner provides no response to these                                
                 arguments.  As we understand the examiner’s arguments, it appears that the                              
                 examiner’s basis for maintaining the rejection is his unsupported premise that                          







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