Ex Parte Ghosh et al - Page 2


                Appeal No.  2006-1021                                                   Page 2                
                Application No.  09/851,882                                                                   
                           of coenzyme Q10 and urea, wherein the ratio of urea to coenzyme                    
                           Q10 in the composition is from about 6:1 to about 10:1 (wt./wt.).                  
                      46. A method of moisturizing the skin, the method comprising applying to                
                           the skin a composition comprising a skin moisturizing effective                    
                           amount of a combination of urea and coenzyme Q10, wherein the                      
                           ratio of urea to coenzyme Q10 in the composition is from about 6:1 to              
                           about 10:1 (wt./wt.).                                                              
                      The references relied upon by the examiner are:                                         
                Bertelli    4,654,373   Mar. 31, 1987                                                         
                Hoppe et al. (Hoppe)  5,889,062   Mar. 30, 1999                                               
                Eucerin Product Insert (Product Insert) (date unavailable)                                    
                EucerinŽ Press Release (Press Release), “EucerinŽ The Medical Skin Care                       
                Program Press Releases,” (Beiersdorf, AG, Hamburg) (date unavailable)                         
                Raab, “Uses of Urea in Cosmetology,” Cosmetics & Toiletries, Vol. 105,                        
                p. 97-102 (1990)                                                                              
                (FDC), “Beiersdorf Eucerin Plus with 5% sodium lactate, 5% urea is for ‘severely              
                dry, scaly skin’,” F-D-C Reports, Vol. 13, No. 43, pp. 14 (1992).                             
                Business Editors/Health & Medical Writers (Business Wire), “Q-Pharma, Inc.-                   
                Grants Non-Exclusive CoQ10 License to Beiersdorf AG,” Business Wire, pp. 1                    
                (Feb. 1, 1999) (ProQuest abstract only)                                                       
                EucerinŽ Medical Site (Eucerin), “EucerinŽ Q10 Anti-Wrinkle Sensitive Skin                    
                Creme,” http://www.eucerinus.com/medicalsite/products/facialcare/q10/q0.html                  
                (2002)                                                                                        


                                         GROUNDS OF REJECTION                                                 
                      I.    Claims 1-13, 17-29, and 32-68 stand rejected under 35 U.S.C. § 103                
                as being unpatentable over the combination of Hoppe and Raab.                                 




                      II.  Claims 1-12, 14, 15, 17, 19, 20, 21, 23, 24, 29, 30, 34, 35, 38-41,                






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