Ex Parte Krieger et al - Page 7


                     Appeal No. 2006-1993                                                                            Page 7                         
                     Application No. 10/147,651                                                                                                     

                              Again, the examiner has provided no evidence or scientific reasoning to                                               
                     support those assertions, and thus has not met his burden in demonstrating that                                                
                     the specification fails to enable the full scope of the claimed subject matter.  In                                            
                     addition, a claim may encompass inoperative embodiments and still meet the                                                     
                     enablement requirement of 35 U.S.C. § 112, first paragraph.  See Atlas Powder                                                  
                     Co. v. E.I. Du Pont De Nemours & Co., 750 F.2d 1569, 1576, 224 USPQ 409,                                                       
                     413 (Fed. Cir. 1984), In re Angstadt, 537 F.2d 498, 504, 190 USPQ 214, 218                                                     
                     (CCPA 1976), In re Cook, 439 F.2d 730, 732, 169 USPQ 298, 300 (CCPA 1971).                                                     
                              Therefore, as the examiner has failed to set forth a prima facie case of                                              
                     unpatentability under 35 U.S.C. § 112, first paragraph, we are compelled to                                                    
                     reverse the rejection.                                                                                                         
                              Claims 13, 15 and 16 stand rejected under 35 U.S.C. § 102(b) as being                                                 
                     anticipated by Baldassarre.                                                                                                    
                              According to the rejection:                                                                                           
                                       Baldassarre teaches the administration of a formulation of                                                   
                              probucol [(4,4’-(isopropylidenedithio)bis(2,6-di-t-butylphenol)], as a                                                
                              therapy to inhibit intimal wall thickening, a process that leads to                                                   
                              atherosclerosis and cardiovascular disease and as a therapy to                                                        
                              decrease total cholesterol (page 788, col. 1, parag. 1 and 2, and                                                     
                              table 2).  The reduction in intimal wall thickening and cholesterol                                                   
                              levels is treatment or prevention of a disorder other than                                                            
                              atherosclerosis.  Baldassarre states that the criteria for entry into                                                 
                              the clinical trial for probucol was primary hyperlipoproteinemia,                                                     
                              which is a disease due to abnormalities in cholesterol metabolism                                                     
                              (page 785, col. 1, parag. 2, lines 1-4).  Thus, Baldassarre clearly                                                   
                              anticipates the claimed invention.                                                                                    
                     Examiner’s Answer, page 6.                                                                                                     








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