Ex Parte Krieger et al - Page 8


                     Appeal No. 2006-1993                                                                            Page 8                         
                     Application No. 10/147,651                                                                                                     

                              In order for a prior art reference to serve as an anticipatory reference, it                                          
                     must disclose every limitation of the claimed invention, either explicitly or                                                  
                     inherently.  See In re Schreiber, 128 F.3d 1473, 1477, 44 USPQ2d 1429, 1432                                                    
                     (Fed. Cir. 1997).                                                                                                              
                              Appellants argue that “Baldasarre describes administering probucol to                                                 
                     patients with atherosclerosis or with a genetic defect causing famial combined                                                 
                     hyperlipedemia,” and that “[t]he first group is specifically excluded by the claims;                                           
                     the second is not mediated by SR-BI, but a defect in a different protein involved                                              
                     in hypercholestermia.”  Appeal Brief, page 14.  We agree, and the rejection is                                                 
                     reversed.                                                                                                                      
                              The examiner argues that “Baldassarre teaches the administration of                                                   
                     probucol to atherosclerosis patients to decrease serum cholesterol.  SR-BI                                                     
                     mediates an increase in serum cholesterol.”  Examiner’s Answer, page 9.  But as                                                
                     noted by appellants, the study “was for the express purpose of treating or                                                     
                     preventing atherosclerosis,” which is specifically excluded by the claim language.                                             
                     Reply Brief, page 7.                                                                                                           
                              Claims 13-16 stand rejected under 35 U.S.C. § 102(b) as being                                                         
                     anticipated by Azen.                                                                                                           
                              According to the rejection:                                                                                           
                                       Azen teaches the oral administration of vitamin E and                                                        
                              vitamin C to patients reduces the levels of total cholesterol and LDL                                                 
                              cholesterol (page 2370, Table 1).  Further, Azen teaches that                                                         
                              administration of vitamin C decreases intima thickness (page 2371,                                                    
                              column 1, paragraph 3).  Azen also discloses that vitamin E                                                           
                              reduced coronary artery lesion progression (page 2371, col. 1,                                                        
                              parag. 2, lines 5-9).  Each of reducing levels of total cholesterol,                                                  





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